alpha Actinin 4 antibody

Catalog No. ABIN733778

The Rabbit Polyclonal anti-alpha Actinin 4 antibody is suitable to detect alpha Actinin 4 in samples from Human. It has been validated for WB, IF, FACS, IHC (p) and IHC (fro).

Quick Overview for alpha Actinin 4 antibody (ABIN733778)

Target: alpha Actinin 4 (ACTN4) (Actinin, alpha 4 (ACTN4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This alpha Actinin 4 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-alpha Actinin 4 Antibody

Purpose: alpha Actinin 4 Polyclonal Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Actinin alpha 4

Isotype: IgG

Application Details

Application Notes: WB(1:500-2000), IHC-P(1:100-500), IHC-F(1:100-500), IF(1:100-500), Flow-Cyt(1 μg/Test)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for alpha Actinin 4

Target: alpha Actinin 4 (ACTN4) (Actinin, alpha 4 (ACTN4))

Alternative Name: alpha Actinin 4

Background:

Synonyms: Actinin alpha 4, alpha-Actinin 4, alpha Actinin-4, actinin 4, actinin4, actinin-4, ACTN 4, ACTN4, DKFZp686K23158, F actin cross linking protein, FSGS 1, FSGS, FSGS1, Non muscle alpha actinin 4.

Background: Loading Control Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008].

Gene ID: 81

Pathways: Proton Transport