Beclin 1 antibody

Catalog No. ABIN7672911

The Mouse Monoclonal anti-Beclin 1 antibody has been validated for WB, ELISA and IHC. It is suitable to detect Beclin 1 in samples from Human, Mouse and Rat.

Quick Overview for Beclin 1 antibody (ABIN7672911)

Target: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Beclin 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Clone: 1G5

Product Details anti-Beclin 1 Antibody

Purpose: BECN1 antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 141-450

Immunogen: beclin 1, autophagy related

Isotype: IgG1

Application Details

Application Notes: WB: 1:500 - 1:5000, IHC: 1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for Beclin 1

Target: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Alternative Name: BECN1

Background:

Synonyms: Beclin-1|Coiled-coil myosin-like BCL2-interacting protein|Protein GT197|Beclin-1-C 35 kDa|Beclin-1-C 37 kDa|BECN1|GT197

Background: Beclin-1(BECN1), also known as ATG6 or VPS30, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. Beclin-1, may play a role in antiviral host defense. It protects against infection by a neurovirulent strain of Sindbis virus. Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. A progressively reduced Beclin-1 expression is reported to correlate with the primary tumor growth of squamous cell carcinoma and adenocarcinoma of the lung. Caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy.

Molecular Weight: 60 kDa

Gene ID: 8678

UniProt: Q14457

Pathways: Autophagy