SIRPA antibody (FITC)

Catalog No. ABIN7673203

This anti-SIRPA antibody is a Rat Monoclonal antibody detecting SIRPA in FACS. Suitable for Mouse.

Quick Overview for SIRPA antibody (FITC) (ABIN7673203)

Target: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This SIRPA antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Clone: P84

Product Details anti-SIRPA Antibody (FITC)

Purpose: FITC Anti-Mouse CD172a/SIRPα Antibody

Purification: 0

Purity: 0

Isotype: IgG1, kappa

Application Details

Application Notes: Volume per test: 5μL. Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 μL of antibody per test (million cells in 100 μL staining volume or per 100 μL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0. 1 % sodium azide, 1 % BSA, pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: 4 °C

Storage Comment: 2-8°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for SIRPA

Target: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Alternative Name: CD172a

Background:

Synonyms: BIT|CD172 antigen-like family member A|P84|PTPNS1|SHPS-1|SIRPα

Background: CD172a, also known as SIRPα, is a type I transmembrane protein with one V-set Ig-like and two C-set Ig-like domains in the extracellular portion, and two ITIM motifs and a proline-rich region in the cytoplasmic tail. CD172a is expressed by monocytes, macrophages, myeloid cells, and neuronal tissue. The phosphorylation of SIRPα ITIMs induces the recruitment and activation of the tyrosine phosphatases PTPN6 and PTPN11, resulting in the negative regulation of several biological processes. The ligands of CD172a are CD47, SP-A, and SP-D.

Molecular Weight: 0

Gene ID: 19261

UniProt: P97797