GSDMD antibody (AA 276-484)

Catalog No. ABIN7673340

The Mouse Monoclonal anti-GSDMD antibody is suitable to detect GSDMD in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and IF.

Quick Overview for GSDMD antibody (AA 276-484) (ABIN7673340)

Target: GSDMD (Gasdermin D (GSDMD))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This GSDMD antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Clone: 10D7

Product Details anti-GSDMD Antibody

Binding Specificity: AA 276-484

Purpose: GSDMD antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 276-484aa

Immunogen: gasdermin D

Isotype: IgG2a

Application Details

Application Notes: WB: 1:1000-1:5000, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for GSDMD

Target: GSDMD (Gasdermin D (GSDMD))

Alternative Name: GSDMD

Background:

Synonyms: Gasdermin-D|Gasdermin domain-containing protein 1|Gasdermin-D, C-terminal (GSDMD-CT, hGSDMD-CTD)|Gasdermin-D, p13|Gasdermin-D, 13 kDa (13 kDa GSDMD)|Gasdermin-D, p40|GSDMD|DFNA5L|GSDMDC1

Background: GSDMD is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. GSDMD has been suggested to act as a tumor suppressor. Recently, GSDMD is identified as a new component of inflammasomes, and it is an executor of pyroptosis and required for interleukin-1β secretion. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.

Molecular Weight: 47-53 kDa

Gene ID: 79792

UniProt: P57764

Pathways: Inflammasome