IRAK3 antibody (AA 428-596)

Catalog No. ABIN7673412

The Rabbit Polyclonal anti-IRAK3 antibody has been validated for WB, ELISA and IHC. It is suitable to detect IRAK3 in samples from Human.

Quick Overview for IRAK3 antibody (AA 428-596) (ABIN7673412)

Target: IRAK3 (Interleukin-1 Receptor-Associated Kinase 3 (IRAK3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRAK3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-IRAK3 Antibody

Binding Specificity: AA 428-596

Purpose: IRAK3 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 428-596aa

Immunogen: IRAK3

Isotype: IgG

Application Details

Application Notes: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for IRAK3

Target: IRAK3 (Interleukin-1 Receptor-Associated Kinase 3 (IRAK3))

Alternative Name: IRAK3

Background:

Synonyms: Interleukin-1 receptor-associated kinase 3 (IRAK-3)|IL-1 receptor-associated kinase M (IRAK-M)|Inactive IL-1 receptor-associated kinase 3|IRAK3

Background: This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants.

Molecular Weight: 68 kDa

Gene ID: 11213

UniProt: Q9Y616

Pathways: TLR Signaling, Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades