SPTBN1 antibody

Catalog No. ABIN7674529

The Rabbit Polyclonal anti-SPTBN1 antibody (ABIN7674529) specifically detects SPTBN1 in WB, ELISA, IHC and IP. The antibody is reactive with Human and Mouse samples.

Quick Overview for SPTBN1 antibody (ABIN7674529)

Target: SPTBN1 (Spectrin Beta, Non-Erythrocytic 1 (SPTBN1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPTBN1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Product Details anti-SPTBN1 Antibody

Purpose: SPTBN1-Specific antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: spectrin, beta, non-erythrocytic 1

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:5000, IP:1:200-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for SPTBN1

Target: SPTBN1 (Spectrin Beta, Non-Erythrocytic 1 (SPTBN1))

Alternative Name: SPTBN1

Background:

Synonyms: Spectrin beta chain, non-erythrocytic 1|Beta-II spectrin|Fodrin beta chain|Spectrin, non-erythroid beta chain 1|SPTBN1|SPTB2

Background: SPTBN1 is the non-erythrocytic form of β-spectrin or β-fodrin. Spectrins are members of the superfamily of F-actin cross linking proteins that are important as scaffolding proteins for protein sorting, cell adhesion, and migration. Reduced expression of SPTBN1 has been found to correlate with shorter survival of patients with hepatocellular cancer, pancreatic cancer and other malignancies of the gastrointestinal tract, suggesting tumor suppression ability of this protein.

Molecular Weight: 275 kDa

UniProt: Q01082

Pathways: Regulation of Actin Filament Polymerization, Protein targeting to Nucleus