Endoglin antibody (FineTest®700)

Catalog No. ABIN7675479

This Rat Monoclonal antibody specifically detects Endoglin in FACS. It exhibits reactivity toward Mouse.

Quick Overview for Endoglin antibody (FineTest®700) (ABIN7675479)

Target: Endoglin (ENG)

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This Endoglin antibody is conjugated to FineTest®700

Application: Flow Cytometry (FACS)

Clone: MJ7-18

Product Details anti-Endoglin Antibody (FineTest®700)

Purpose: FineTest®700 Anti-Mouse CD105 Antibody

Isotype: IgG2a, kappa

Application Details

Application Notes: Volume per test: 5μL. Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 μL of antibody per test (million cells in 100 μL staining volume or per 100 μL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0. 1 % sodium azide, 1 %BSA, pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: 4 °C

Storage Comment: 2-8°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for Endoglin

Target: Endoglin (ENG)

Alternative Name: CD105

Background:

Synonyms: END|Endoglin|Eng

Background: CD105 is a 90 kD homodimeric type I integral membrane glycoprotein, also known as endoglin. It is expressed on endothelial cells (especially on angiogenic endothelial cells) and upregulated by hypoxia, activated monocytes, macrophages, bone marrow stromal cells, and some cytotrophoblasts. CD105 is a receptor for TGF-β1, TGF-β3 and modulates TGF-β signaling by interacting with TGF-β receptors I and/or II. CD105 also binds other growth factors such as actvin A, BMP-2, and BMP-7. CD105 has been show to be a useful marker for identifying proliferating endothelium involved in tumor angiogenesis and can be used for tumor imaging and prognosis, and has therapeutic potential for some solid tumors and other angiogenic diseases.

Molecular Weight: 0

Gene ID: 13805

UniProt: Q63961