CCKBR antibody (AA 301-400)

Catalog No. ABIN734318

Product Details anti-CCKBR Antibody

Target: CCKBR (Cholecystokinin B Receptor (CCKBR))

Binding Specificity: AA 301-400

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCKBR antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Cow,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Gastrin receptor

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-CCKBR antibody (ABIN734318)

Eberhard, Kirkeby, Hansen, Cayé-Thomasen: "Neurotransmitter and neurotransmitter receptor expression in the saccule of the human vestibular system." in: Progress in neurobiology, Vol. 212, pp. 102238, (2022) (PubMed).

Liu, Banerjee, Herring, Attalla, Hu, Xu, Shao, Simmons, Dadi, Wang, Jacobson, Liu, Hodges, Lau, Gu: "Neurog3-Independent Methylation Is the Earliest Detectable Mark Distinguishing Pancreatic Progenitor Identity." in: Developmental cell, Vol. 48, Issue 1, pp. 49-63.e7, (2019) (PubMed).

Mohammad, Ozaki, Takeuchi, Unno, Yamoto, Morioka, Takiguchi, Ikeda: "Functional compensation between cholecystokinin-1 and -2 receptors in murine paraventricular nucleus neurons." in: The Journal of biological chemistry, Vol. 287, Issue 47, pp. 39391-401, (2012) (PubMed).

Kalsheker, Hodgson, Watkins, White, Morrison, Stockley: "Deoxyribonucleic acid (DNA) polymorphism of the alpha 1-antitrypsin gene in chronic lung disease." in: British medical journal (Clinical research ed.), Vol. 294, Issue 6586, pp. 1511-4, (1987) (PubMed).

Target Details for CCKBR

Target: CCKBR (Cholecystokinin B Receptor (CCKBR))

Alternative Name: Gastrin receptor/GASR/CCKBR (CCKBR Products)

Synonyms: CCKBR antibody, LOC100232835 antibody, CCK-B antibody, CCK2R antibody, GASR antibody, Cck2r antibody, Cholrec antibody, CCKR-2 antibody, CCK-BR antibody, CCK2-R antibody, CCK-CHR antibody, cholecystokinin B receptor antibody, cholecystokinin receptor-like antibody, CCKBR antibody, LOC100232835 antibody, Cckbr antibody

Background:

Synonyms: GASR, CCK-B, CCK2R, Gastrin/cholecystokinin type B receptor, CCK-B receptor, CCK-BR, Cholecystokinin-2 receptor, CCK2-R, CCKBR, CCKRB

Background: Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.

Gene ID: 887

UniProt: P32239

Pathways: Positive Regulation of Peptide Hormone Secretion, Feeding Behaviour