Integrin Alpha3, Beta1 (AA 976-1025) antibody (HRP)

Catalog No. ABIN737040

This anti- antibody is a Rabbit Polyclonal antibody detecting in WB, ELISA, IHC (fro) and IHC (p). Suitable for Human, Mouse and Rat.

Quick Overview for Integrin Alpha3, Beta1 (AA 976-1025) antibody (HRP) (ABIN737040)

Target: Integrin Alpha3, Beta1

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details

Binding Specificity: AA 976-1025

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: Mixed KLH conjugated synthetic peptide derived from human Integrin Alpha 3(976-1025/1051) + Beta 1(35-47/798)

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: Integrin Alpha3, Beta1

Alternative Name: Integrin Alpha 3 + Beta 1

Background:

Synonyms: Integrin Alpha 3 / Beta 1, Integrin VLA 4 beta subunit, Alpha 3 subunit of VLA 3 receptor, CD29, CD49C, Fibronectin receptor, Fibronectin receptor beta subunit, Galactoprotein B3, GAPB3, VL3A, VLA 3 alpha chain, VLA3a.

Background: alpha3beta1 integrin is a laminin receptor with apparently diverse functions. In epithelial cells it acts as a receptor for the basement membrane, whereas in neuronal and possibly tumor cells it mediates migration. Interactions of alpha3beta1 integrin with tetraspanin proteins may provide clues to how it transduces signals that affect cell behavior.

Gene ID: 3675, 3688

UniProt: P26006, P05556