Lipoarabinomannan (LAM) antibody

Catalog No. ABIN7794694

The Rabbit Monoclonal anti-Lipoarabinomannan antibody (Clone MYCO-5936) (ABIN7794694) specifically detects Lipoarabinomannan in ELISA and IF. The antibody is reactive with Mycobacteria samples.

Quick Overview for Lipoarabinomannan (LAM) antibody (ABIN7794694)

Target: Lipoarabinomannan (LAM)

Reactivity: Mycobacteria

Host: Rabbit

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: ELISA, Immunofluorescence (IF)

Clone: MYCO-5936

Product Details

Purpose: Anti-Mycobacteria, LAM (MYCO-5936)

Specificity: Anti-Mycobacteria (Clone MYCO-5936) is specific for the lipoarabinomannan of several Mycobacteria species including Mycobacterium tuberculosis (6 strains), M. bovis, M. smegmatis, M. leprae, M. avium, M. phlei, & M. parafortuitum. Background Mycobacterium is a diverse genus of bacteria that includes several pathogenic species responsible for causing diseases in humans, most notably Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). Mycobacteria are characterized by their unique cell wall structure, which contains high levels of mycolic acids, making them resistant to many conventional antibiotics. In addition to M. tuberculosis, other medically important species include Mycobacterium leprae, responsible for leprosy, and Mycobacterium avium complex (MAC), causing opportunistic infections in immunocompromised individuals. Mycobacterium cell walls also contain a glycolipid known as Lipoarabinomannan (LAM), which plays a significant role in pathogenesis. LAM helps the bacteria evade the host immune system and modulate the host's inflammatory response. Additionally, LAM has been used as a diagnostic marker for TB infection, as it can be detected in patient samples such as sputum and urine. Understanding the unique characteristics of Mycobacterium and the role of molecules like LAM is crucial for the development of effective diagnostic tools and therapeutic strategies to combat mycobacterial infections.

Purification: This monoclonal antibody is purified by protein A chromatography or sequential differential precipitations.

Purity: >=90 %

Isotype: IgG

Application Details

Application Notes: ELISA: 1:20-1:200,IF: 1:10-1:50

Restrictions: For Research Use only

Handling

Concentration: 1 μg/mL

Buffer: Formulated in 0.01 M phosphate buffered saline, pH 7.2 and contains 0.1 % sodium azide. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: This purified antibody is stable when stored at 2-8°C. Do not freeze.

Target Details

Target: Lipoarabinomannan (LAM)

Alternative Name: LAM

Background: LAM, lipoarabinomannan, Mtb, TB, Tuberculosis,