Recombinant PCSK9 (Evolocumab Biosimilar) antibody

Catalog No. ABIN7795143

The Mouse Monoclonal anti-PCSK9 (Evolocumab Biosimilar) antibody is suitable to detect PCSK9 (Evolocumab Biosimilar) in samples from Human. It has been validated for FACS and in vivo.

Quick Overview for Recombinant PCSK9 (Evolocumab Biosimilar) antibody (ABIN7795143)

Target: PCSK9 (Evolocumab Biosimilar)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PCSK9 (Evolocumab Biosimilar) antibody is un-conjugated

Application: Flow Cytometry (FACS), In vivo Studies (in vivo)

Grade: Research Grade

Product Details anti-PCSK9 (Evolocumab Biosimilar) Antibody

Expression System: Mammalian cells

Purpose: Evolocumab Biosimilar, Human PCSK9 Monoclonal Antibody

Characteristics: What is evolocumab biosimilar research grade? Evolocumab (trade name Repatha) is a fully human monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and lowers low-density lipoprotein (LDL) cholesterol levels by approximately 60 % . The PCSK9 protein targets LDL receptors for degradation. Evolocumab binds to the circulating PCSK9 protein, inhibiting it from binding to the LDLR, in turn preventing PCSK9-mediated LDLR degradation and permitting the LDLR to recycle back to the liver cell surface. By inhibiting the binding of PCSK9 to LDLR, evolocumab increases the number of LDLRs available to clear LDL from the blood, thereby lowering LDL-C levels. Evolocumab biosimilar uses the same protein sequences as the therapeutic antibody evolocumab.

Purification: Protein A or G affinity column

Purity: >95 % by reducing SDS-PAGE

Endotoxin Level: < 1 EU per 1 mg of the protein by the LAL method

Immunogen: Human PCSK9

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: > 3 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: Short time 2 to 8°C as supplied. Long time -20°C to -70°C as supplied.

Target Details for PCSK9 (Evolocumab Biosimilar)

Target: PCSK9 (Evolocumab Biosimilar)

Alternative Name: Evolocumab Biosimilar

Target Type: Biosimilar