Plau/Urokinase antibody (HRP)

Catalog No. ABIN737640

The HRP-conjugated Rabbit Polyclonal anti-Plau/Urokinase antibody (ABIN737640) specifically detects Plau/Urokinase in WB and IHC (p). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Plau/Urokinase antibody (HRP) (ABIN737640)

Target: Plau/Urokinase

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: HRP

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from rat PLAU

Isotype: IgG

Application Details

Application Notes: WB: (1:100-1000), IHC-P: (1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Gentamicin sulfate

Precaution of Use: This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: Plau/Urokinase

Background:

Synonyms: Urokinase, ATF, ATF uPA, Plasminogen activator, Plasminogen activator urinary, Plasminogen activator urokinase, PLAU, u PA, U plasminogen activator, UPA, URK, Urokinase plasminogen activator, Urokinase type plasminogen activator, Urokinase type plasminogen activator precursor.

Background: Urokinase is a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in the Urokinase gene may be associated with late onset Alzheimer disease and also with decreased affinity for fibrin binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg Val bond in plasminogen. The proprotein is cleaved at a Lys Ile bond by plasmin to form a two chain derivative in which a single disulfide bond connects the amino terminal A chain to the catalytically active, carboxy terminal B chain. This two chain derivative is also called HMW uPA (high molecular weight uPA). HMW uPA can be further processed into LMW uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino terminal fragment. LMW uPA is proteolytically active but does not bind to the uPA receptor.

Gene ID: 5328