C3 antibody

Catalog No. ABIN739333

This Goat Polyclonal antibody specifically detects C3 in WB, ELISA, IHC (fro), IF (p), IHC (p) and IF (cc). It exhibits reactivity toward Mouse.

Quick Overview for C3 antibody (ABIN739333)

Target: C3 (Complement Component 3 (C3))

Reactivity: Mouse

Host: Goat

Clonality: Polyclonal

Conjugate: This C3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Product Details anti-C3 Antibody

Cross-Reactivity: Mouse

Predicted Reactivity: Human

Purification: Purified by Protein A.

Immunogen: human Complement C3 purified from human plasma

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for C3

Target: C3 (Complement Component 3 (C3))

Alternative Name: Complement C3

Background:

Synonyms: Acylation stimulating protein cleavage product, Acylation-stimulating protein cleavage product, AHUS5, ARMD9, ASP, ASP, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1 antibody C3 antibody C3a anaphylatoxin, CO3_HUMAN, Complement C3 alpha chain, Complement C3, Complement C3 beta chain, Complement C3 precursor, Complement C3b alpha chain, Complement C3c alpha' chain fragment 2, Complement C3c fragment, Complement C3d fragment, Complement C3f fragment, Complement C3g fragment, Complement component 3, Complement component 3 precursor, Complement component C3, Complement factor 3, CPAMD1, Plp.

Background: The complement factor C3 consists of an alpha and a beta chain. C3 is a central factor in the complement cascade. It is central to the alternative pathway that leads to the C3 convertase C3bBb. The classical mannose binding lectin activation pathway leads to the C3 convertase C4b2a. These convertases cleave C3 resulting in C3a and C3b. Further degradation leads to the formation of the alpha chain products C3d, C3g and C3c. C3 is an acute phase protein that is produced by a wide range of tissues, including renal epithelial cells and hepatocytes.

Gene ID: 718

Pathways: Complement System, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Regulation of G-Protein Coupled Receptor Protein Signaling