Recombinant HMGCR antibody

Catalog No. ABIN7827985

This Rabbit Monoclonal antibody specifically detects HMGCR in WB, IP, FACS and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for Recombinant HMGCR antibody (ABIN7827985)

Target: HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This HMGCR antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: A254

Product Details anti-HMGCR Antibody

Purpose: Recombinant HMGCR Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human HMG-CoA Reductase fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:500-1:2000,IF 1:50,FCM 1:50-1:100,IP 1:25

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for HMGCR

Target: HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))

Alternative Name: HMGCR

Background: LDLCQ,HMGCR,LDLCQ3,3-hydroxy-3-methylglutaryl-CoA reductase,3-hydroxy-3-methylglutaryl-CoA reductase,LDLCQ3,3-hydroxy-3-methylglutaryl-coenzyme A reductase,HMG-CoA reductase,3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is a transmembrane glycoprotein of the endoplasmic reticulum. It is the rate-limiting enzyme for cholesterol biosynthesis and non-sterol isoprenoid biosynthesis. Play a key role in cellular cholesterol homeostasis. The activity of HMGCR is regulated by negative feedback, in which cholesterol and other end products of the metabolic pathway inhibit the activity of HMGCR in a multivalent manner. Cholesterol inhibits reductase activity mainly by inhibiting the transcription rate of HMGCR gene. HMGCR is the main target of statins, which are a class of cholesterol-lowering drugs. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 97 kDa

Observed MW: 97 kDa

UniProt: P04035

Pathways: AMPK Signaling, Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha