Recombinant ANGPTL3 antibody

Catalog No. ABIN7828020

The Rabbit Monoclonal anti-ANGPTL3 antibody (Clone A133) (ABIN7828020) specifically detects ANGPTL3 in WB, IHC and IF. The antibody is reactive with Human and Mouse samples.

Quick Overview for Recombinant ANGPTL3 antibody (ABIN7828020)

Target: ANGPTL3 (Angiopoietin-Like 3 (ANGPTL3))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ANGPTL3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Clone: A133

Product Details anti-ANGPTL3 Antibody

Purpose: Recombinant ANGPTL3 Monoclonal Antibody

Purification: Protein A purified

Immunogen: Synthetic peptide derived from ANGPTL3 anti

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:500-1:1000,IHC 1:50-1:100,IF 1:50

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for ANGPTL3

Target: ANGPTL3 (Angiopoietin-Like 3 (ANGPTL3))

Alternative Name: ANGPTL3

Background: ANG,UNQ,PRO,FHBL,Angiopoietin,angiopoietin like,Angiopoietin-like protein,Angiopoietin-related protein,ANGPT,ANGPTL,ANGPTL3,ANG-5,ANGPT5,ANL3,FHBL2,angiopoietin like 3,Angiopoietin-5,Angiopoietin-like protein 3,Angiopoietin-related protein 3,ANL,UNQ153,PRO179,ANG-5,ANGPT5,ANL3,FHBL2,Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism. Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake. Has a stimulatory effect on plasma triglycerides (TG), which is achieved by suppressing plasma TG clearance via inhibition of LPL activity. The inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface, the function does not require ANGPTL3 proteolytic cleavage but seems to be mediated by the N-terminal domain, and is not inhibited by GPIHBP1. Can inhibit endothelial lipase, causing increased plasma levels of high density lipoprotein (HDL) cholesterol and phospholipids. Can bind to adipocytes to activate lipolysis, releasing free fatty acids and glycerol. Suppresses LPL specifically in oxidative tissues which is required to route very low density lipoprotein (VLDL)-TG to white adipose tissue (WAT) for storage in response to food, the function may involve cooperation with circulating, liver-derived ANGPTL8 and ANGPTL4 expression in WAT. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 54 kDa

Observed MW: 54 kDa

UniProt: Q9Y5C1