Recombinant Caveolin 3 antibody

Catalog No. ABIN7828073

The Rabbit Monoclonal anti-Caveolin 3 antibody is suitable to detect Caveolin 3 in samples from Human, Mouse and Rat. It has been validated for WB and IHC.

Quick Overview for Recombinant Caveolin 3 antibody (ABIN7828073)

Target: Caveolin 3 (CAV3)

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Caveolin 3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: A631

Product Details anti-Caveolin 3 Antibody

Purpose: Recombinant Caveolin-3 Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human Caveolin-3 fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:1000,IHC 1:100-1:400

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for Caveolin 3

Target: Caveolin 3 (CAV3)

Alternative Name: Caveolin-3

Background: LQT,CAV,VIP,CAV3,LGMD1C,LQT9,VIP-21,VIP21,Caveolin 3,Caveolin-3,M-caveolin,MGC126100,MGC126101,MGC126129,OTTHUMP00000115603,OTTHUMP00000207105,VIP 21,The 21-24 kDa integral proteins, caveolins, are the principal structural components of the cholesterol/sphingolipid-enriched plasma membrane microdomain caveolae. Three members of the caveolin family (caveolin-1, -2, and -3) have been identified with different tissue distributions. Caveolins form hetero- and homo-oligomers that interact with cholesterol and other lipids. Caveolins are involved in diverse biological functions, including vesicular trafficking, cholesterol homeostasis, cell adhesion, and apoptosis, and are also implicated in neurodegenerative disease. Caveolins interact with multiple signaling molecules, such as Gα subunit, tyrosine kinase receptors, PKCs, Src family tyrosine kinases, and eNOS. It is believed that caveolins serve as scaffolding proteins for the integration of signal transduction. Phosphorylation at Tyr14 is essential for caveolin association with SH2 or PTB domain-containing adaptor proteins, such as GRB7. Phosphorylation at Ser80 regulates caveolin binding to the ER membrane and entry into the secretory pathway. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 17 kDa

Observed MW: 17 kDa

UniProt: P56539

Pathways: Carbohydrate Homeostasis, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Skeletal Muscle Fiber Development, Negative Regulation of Transporter Activity