Recombinant CD8B antibody

Catalog No. ABIN7828095

The Rabbit Monoclonal anti-CD8B antibody (Clone A702) (ABIN7828095) specifically detects CD8B in WB and IHC. The antibody is reactive with Mouse samples.

Quick Overview for Recombinant CD8B antibody (ABIN7828095)

Target: CD8B (CD8b Molecule (CD8B))

Antibody Type: Recombinant Antibody

Reactivity: Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CD8B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: A702

Product Details anti-CD8B Antibody

Purpose: Recombinant CD8 beta Monoclonal Antibody

Purification: Protein A purified

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:1000,IHC 1:100

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for CD8B

Target: CD8B (CD8b Molecule (CD8B))

Alternative Name: CD8 beta

Background: LYT,LEU,CD8B,CD8B1,LEU2,LY3,LYT3,P37,T-Cell Surface Glycoprotein CD8 Beta Chain,CD8,Lyt3,Cluster of Differentiation 8 (CD8) is a disulphide-linked heterodimer consisting of the unrelated α and β subunits. Each subunit is a glycoprotein composed of a single extracellular Ig-like domain, a polypeptide linker, a transmembrane part and a short cytoplasmic tail. On T cells, CD8 is the coreceptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen-Major Histocompatibility Complex (MHC). Specifically, the Ig-like domain of CD8α interacts with the α3-domain of the MHC class I molecule. CD8 ensures specificity of the TCR-antigen interaction, prolongs the contact between the T cell and the antigen presenting cell, and the α chain recruits the tyrosine kinase Lck, which is essential for T cell activation. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 24 kDa

Observed MW: 28-32 kDa The actual band is not consistent with the expectation.

UniProt: P10966

Pathways: TCR Signaling