Recombinant COPS3 antibody

Catalog No. ABIN7828134

The Rabbit Monoclonal anti-COPS3 antibody (Clone A192) (ABIN7828134) specifically detects COPS3 in WB, IHC and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Recombinant COPS3 antibody (ABIN7828134)

Target: COPS3 (COP9 Signalosome Complex Subunit 3 (COPS3))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This COPS3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Clone: A192

Product Details anti-COPS3 Antibody

Purpose: Recombinant COPS3 Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human COPS3 fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:500-1:1000,IHC 1:50-1:100,IF 1:50

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for COPS3

Target: COPS3 (COP9 Signalosome Complex Subunit 3 (COPS3))

Alternative Name: COPS3

Background: SGN,Csn,COPS,COPS3,CSN3,SGN3,Constitutive photomorphogenic homolog subunit 3,COP 9 (constitutive photomorphogenic) subunit 3,COP 9 complex homolog subunit 3,COP 9 complex S3,COP 9 complex subunit 3,COP 9 constitutive photomorphogenic homolog subunit 3,COP 9 homolog,COP 9 signalosome complex subunit 3,COP 9 signalosome subunit 3,COP 9 subunit 3,COP9 (constitutive photomorphogenic) subunit 3,COP9 complex homolog subunit 3,COP9 complex S3,COP9 complex subunit 3,COP9 constitutive photomorphogenic homolog subunit 3,COP9 homolog,COP9 signalosome complex subunit 3,COP9 signalosome subunit 3,COP9 subunit 3,COPS 3,CSN 3,JAB 1 containing signalosome subunit 3,JAB1 containing signalosome subunit 3,JAB1-containing signalosome subunit 3,SGN 3,Signalosome subunit 3,Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 44 kDa

Observed MW: 44 kDa

UniProt: Q9UNS2

Pathways: Cell Division Cycle