Recombinant CD74 antibody

Catalog No. ABIN7828290

The Rabbit Monoclonal anti-CD74 antibody (Clone A535) (ABIN7828290) specifically detects CD74 in FACS, WB and IHC. The antibody is reactive with Human samples.

Quick Overview for Recombinant CD74 antibody (ABIN7828290)

Target: CD74 (HLA-DR-gamma (CD74))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CD74 antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (IHC)

Clone: A535

Product Details anti-CD74 Antibody

Purpose: Recombinant CD74 Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human CD74 fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:500-1:2000,IHC 1:2000-1:5000,FCM 1:50

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for CD74

Target: CD74 (HLA-DR-gamma (CD74))

Alternative Name: CD74

Background: HLA class II histocompatibility antigen gamma chain,HLADG,Ia antigen-associated invariant chain,Ia-GAMMA II,Ii,p33,CD74 HLA-DR antigens-associated invariant chain,DHLAG,CD74,invariant chain,CD 74,CD74 antigen,CD74 antigen (invariant polypeptide of major histocompatibility complex,CD74 Molecule,class II antigen-associated),class II invariant chain,CLIP,Gamma chain of class II antigens,HG2A,HLA DR antigens associated invariant chain,HLA DR gamma,HLADR antigens associated invariant chain,HLA-DR antigens-associated invariant chain,HLA-DR-gamma,Ia antigen associated invariant chain,Ia associated invariant chain,Ia gamma,Ia-GAMMA,Invariant polypeptide of major histocompatibility complex class II antigen associated,la-gamma,major histocompatibility complex,Major histocompatibility complex class II invariant chain,MHC HLA DR gamma chain,MHC HLA-DR gamma chain,p35,Protein 41,CD74,DHLAG,HLA class II histocompatibility antigen gamma chain,HLADG,Ia antigen-associated invariant chain,p33,CD 14,CD_antigen=CD14,CD14,CD14 antigen,CD14 Molecule,LPS-R,Mo2,Monocyte differentiation antigen CD14,Monocyte differentiation antigen CD14 urinary form,membrane-bound form,Myeloid cell specific leucine rich glycoprotein,Myeloid cell-specific leucine-rich glycoprotein,CD74, also known as the MHC Class II-associated invariant chain (Ii), is a type II transmembrane glycoprotein that plays a critical role in the antigen presentation process as a chaperone of MHC Class II proteins. It is expressed at high levels on B cells and to a lesser extent on numerous antigen presenting cell (APC) types including dendritic cells, Langerhans cells, monocytes, and macrophages as well as non-traditional APCs such as epithelial cells. CD74 was initially identified for its ability to regulate the folding and intracellular trafficking of newly synthesized MHC Class II molecules. Following expression, CD74 self-assembles as a trimer that serves as a scaffold for the assembly of MHC Class II molecules. Through this interaction, CD74 blocks the peptide binding cleft of MHC Class II molecules and prevents their premature association with endogenous polypeptides. Binding to CD74 also facilitates the translocation of MHC Class II molecules from the endoplasmic reticulum to the endocytic compartments during antigen presentation. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 34 kDa

Observed MW: 34 kDa

UniProt: P04233

Pathways: Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints