Recombinant MAP2K5 antibody

Catalog No. ABIN7828398

The Rabbit Monoclonal anti-MAP2K5 antibody (Clone A623) (ABIN7828398) specifically detects MAP2K5 in WB. The antibody is reactive with Human samples.

Quick Overview for Recombinant MAP2K5 antibody (ABIN7828398)

Target: MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MAP2K5 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: A623

Product Details anti-MAP2K5 Antibody

Purpose: Recombinant MEK5 Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human MEK5 fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:1000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for MAP2K5

Target: MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))

Alternative Name: MEK5

Background: MEK,MKK,MAP2K,MAPKK,PRKMK,MAP2K5,HsT17454,MAPKK5,MEK5,PRKMK5,MKK5,Dual specificity mitogen activated protein kinase kinase 5,Dual specificity mitogen-activated protein kinase kinase 5,EC 2.7.12.2,kinase 5,MAP kinase kinase 5,MAP kinase kinase MEK5b,MAPK/ERK kinase 5,MAPKK 5,MEK 5,mitogen-activated,mitogen-activated protein kinase kinase 5,MP2K5,Protein kinase,SAPKK5,SKK5,MEK5 is a dual specific kinase that specifically activates ERK5 involved in the regulation of diverse cellular processes, including cell growth, survival, and differentiation. The MEK5-ERK5 pathway is activated in numerous cancer types and plays a role in tumor growth and metastasis. Pharmacological targeting of the MEK5-ERK5 pathway has been investigated as a strategy for cancer treatment. MEK5 is activated by a variety of stimuli, including growth factors, cytokines, and oxidative stress. Activation of MEK5 is triggered by upstream kinases MEKK2 and MEKK3, leading to phosphorylation of MEK5 at Ser311 and Thr315, which subsequently leads to MEK5 dependent phosphorylation of EKR5 at Thr218 and Tyr220. Phosphorylation of ERK5 leads to nuclear translocation and regulation of several oncogenic transcription factors, including MEF2C, c-Fos, c-Myc, and Sap1. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 49, 50 kDa

Observed MW: 49, 50 kDa

UniProt: Q13163

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway