Recombinant PNKP antibody

Catalog No. ABIN7828469

The Rabbit Monoclonal anti-PNKP antibody is suitable to detect PNKP in samples from Human. It has been validated for WB and IHC.

Quick Overview for Recombinant PNKP antibody (ABIN7828469)

Target: PNKP (Polynucleotide Kinase 3'-Phosphatase (PNKP))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PNKP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: A752

Product Details anti-PNKP Antibody

Purpose: Recombinant PNKP Monoclonal Antibody

Purification: Protein A purified

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:2000,IHC 1:100

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for PNKP

Target: PNKP (Polynucleotide Kinase 3'-Phosphatase (PNKP))

Alternative Name: PNKP

Background: AOA,EIEE,PNKP,AOA4,EIEE10,MCSZ,PNK,PNK (polynucleotide kinase) is a DNA repair enzyme that participates in single strand break repair and non-homologous end rejoining (NHEJ) for double strand breaks. PNK possesses a 5'-DNA kinase activity and a 3'-DNA phosphatase activity. It has three domains, a C terminal kinase domain, a central phosphatase domain, and an N-terminal forkhead associated (FHA) domain that is responsible for protein protein interactions. Reduction in expression of PNK by RNAi sensitizes cells to ionizing radiation and topoisomerase I inhibitors. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 57 kDa

Observed MW: 60 kDa The actual band is not consistent with the expectation.

UniProt: Q96T60

Pathways: DNA Damage Repair, Nucleotide Phosphorylation