Recombinant PRMT5 antibody

Catalog No. ABIN7828493

The Rabbit Monoclonal anti-PRMT5 antibody is suitable to detect PRMT5 in samples from Human. It has been validated for WB, IHC and IP.

Quick Overview for Recombinant PRMT5 antibody (ABIN7828493)

Target: PRMT5 (Protein Arginine Methyltransferase 5 (PRMT5))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PRMT5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Clone: A338

Product Details anti-PRMT5 Antibody

Purpose: Recombinant PRMT5 Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human PRMT5 fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:2000-1:10000,IHC 1:50-1:100,IP 1:25-1:50

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for PRMT5

Target: PRMT5 (Protein Arginine Methyltransferase 5 (PRMT5))

Alternative Name: PRMT5

Background: IBP,JBP,SKB,PRMT,HRMT1L,HRMT1L5,IBP72,JBP1,SKB1,SKB1Hs,PRMT5,72 kDa ICln binding protein,72 kDa ICln-binding protein,ANM5,Histone synthetic lethal 7,Histone-arginine N-methyltransferase PRMT5,HMT1 hnRNP methyltransferase like 5,homolog of,Jak-binding protein 1,JBP 1,PRMT 5,Protein arginine methyltransferase 5,Protein arginine N methyltransferase 5,Protein arginine N methyltransferase 5 N terminally processed,Protein arginine N-methyltransferase 5,S. cerevisiae,S. POMBE,S. POMBE HOMOLOG OF,SHK1 KINASE BINDING PROTEIN 1,Shk1 kinase binding protein 1 homolog,Shk1 kinase/binding protein 1,Shk1 kinase-binding protein 1 homolog,SKB 1,SKB1 homolog,SKB1: SKB1 homolog (S. pombe),Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3), such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H and may regulate its transcriptional elongation properties. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 73 kDa

Observed MW: 70 kDa The actual band is not consistent with the expectation.

UniProt: O14744

Pathways: Chromatin Binding, Regulation of Muscle Cell Differentiation, Ribonucleoprotein Complex Subunit Organization, Skeletal Muscle Fiber Development