Recombinant TREX1 antibody

Catalog No. ABIN7828620

The Rabbit Monoclonal anti-TREX1 antibody (Clone A643) (ABIN7828620) specifically detects TREX1 in WB. The antibody is reactive with Human samples.

Quick Overview for Recombinant TREX1 antibody (ABIN7828620)

Target: TREX1 (three Prime Repair Exonuclease 1 (TREX1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TREX1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: A643

Product Details anti-TREX1 Antibody

Purpose: Recombinant TREX1 Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human TREX1 fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:1000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for TREX1

Target: TREX1 (three Prime Repair Exonuclease 1 (TREX1))

Alternative Name: TREX1

Background: TREX,Trex1,TREX1 is a broadly expressed 3' to 5' exonuclease that acts on single-stranded DNA (ssDNA) to negatively regulate the interferon-stimulatory DNA (ISD) response. In humans, there are three TREX1 isoforms generated through alternative splicing with predicted molecular weights of 32, 33, and 39 kDa. The transcript for the 33 kDa isoform is the most abundant. Mice deficient in TREX1 accumulate intracellular ssDNA, which triggers the ISD response and eventually lethal autoimmunity. Mutations in TREX1 are associated with autoimmune diseases including Aicardi-Goutieres syndrome and systemic lupus erythematosus. In addition, TREX1 prevents the cell-intrinsic innate immune response to human immunodeficiency virus (HIV) by digesting excess HIV DNA that would normally trigger induction of type I interferon. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 34 kDa

Observed MW: 34 kDa

UniProt: Q91XB0

Pathways: Apoptosis