Recombinant TPX2 antibody

Catalog No. ABIN7828630

This Rabbit Monoclonal antibody specifically detects TPX2 in WB, IHC, IF and FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Recombinant TPX2 antibody (ABIN7828630)

Target: TPX2 (TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TPX2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: A382

Product Details anti-TPX2 Antibody

Purpose: Recombinant TPX2 Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human TPX2 fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:500-1:1000,IHC 1:50-1:200,IF 1:50,FCM 1:50-1:100

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for TPX2

Target: TPX2 (TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2))

Alternative Name: TPX2

Background: FLS,HCA,TPX,HCTP,REPP,GD:C20orf,DIL,DIL2,p100,DIL-2,HCTP4,FLS353,HCA519,REPP86,C20orf1,C20orf2,GD:C20orf1,TPX2,Chromosome 20 Open Reading Frame 1,Differentially expressed in cancerous and noncancerous lung cells 2,Differentially expressed in cancerous and non-cancerous lung cells 2,Differentially expressed in lung cells,Differentially expressed in lung cells 2,DIL 2,HCA 519,HCTP 4,Hepatocellular carcinoma associated antigen 519,Hepatocellular carcinoma-associated antigen 519,Preferentially expressed in colorectal cancer,Protein fls353,REPP 86,Restricted expression proliferation associated protein 100,Restricted expression proliferation-associated protein 100,Targeting protein for Xklp2,TPX 2,TPX2 microtubule associated homolog,TPX2 microtubule associated protein homolog,TPX2 microtubule nucleation factor,Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules.Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha .At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 86 kDa

Observed MW: 100 kDa The actual band is not consistent with the expectation.

UniProt: Q9ULW0