Recombinant STING/TMEM173 antibody

Catalog No. ABIN7828638

The Rabbit Monoclonal anti-STING/TMEM173 antibody (Clone A369) (ABIN7828638) specifically detects STING/TMEM173 in WB, IHC and IF. The antibody is reactive with Human samples.

Quick Overview for Recombinant STING/TMEM173 antibody (ABIN7828638)

Target: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This STING/TMEM173 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Clone: A369

Product Details anti-STING/TMEM173 Antibody

Purpose: Recombinant STING Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human STING fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:500-1:2000,IHC 1:200-1:1000,IF 1:50

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for STING/TMEM173

Target: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Alternative Name: STING

Background: NET,TMEM,TMEM173,ERIS,MITA,MPYS,NET23,SAVI,STING,hMITA,hSTING,Mediator of IRF3 activation,Stimulator of interferon genes protein,STING1,endoplasmic reticulum IFN stimulator,Endoplasmic reticulum interferon stimulator,FLJ38577,Mitochondrial mediator of IRF3 activation,N terminal methionine proline tyrosine serine plasma membrane tetraspanner,Stimulator of interferon genes,TM173,Transmembrane protein 173,STING has several transmembrane domains, and is expressed in a variety of endothelial cells, epithelial cells and hematopoietic liver cells. STING participates in the DNA-mediated innate immune response. Non-CpG double-stranded DNA from viruses or bacteria binds to cGAS protein and is catalyzed to the second messenger cGAMP, then the dimerized STING binds to cGAMP and undergoes conformational changes. Through the autophagsome and the endoplasmic reticulum and the Golgi apparatus, it further enters the cytoplasm. During the period, it is ubiquitinated and recruited TBK1 protein, then phosphorylated, and then combined with IRF3, then IRF3 is phosphorylated and enters the nucleus to induce the expression of IFNs, etc. In conclusion, it can enhance the body's immune ability and kill bacteria, viruses and other pathogens to a greater extent. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 42 kDa

Observed MW: 36 kDa The actual band is not consistent with the expectation.

UniProt: Q86WV6

Pathways: Activation of Innate immune Response