Recombinant TTR antibody

Catalog No. ABIN7828640

The Rabbit Monoclonal anti-TTR antibody is suitable to detect TTR in samples from Human. It has been validated for WB and IHC.

Quick Overview for Recombinant TTR antibody (ABIN7828640)

Target: TTR (Transthyretin (TTR))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TTR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: A768

Product Details anti-TTR Antibody

Purpose: Recombinant Prealbumin/Transthyretin Monoclonal Antibody

Purification: Protein A purified

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:1000,IHC 1:1000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for TTR

Target: TTR (Transthyretin (TTR))

Alternative Name: Prealbumin/Transthyretin

Background: HEL,HsT,TTR,CTS,CTS1,HEL111,HsT2651,PALB,TBPA,ATTR,Prealbumin,Transthyretin,Amyloid polyneuropathy,Amyloidosis I,Carpal tunnel syndrome 1,Dysprealbuminemic euthyroidal hyperthyroxinemia,Dystransthyretinemic hyperthyroxinemia,Epididymis luminal protein 111,Prealbumin amyloidosis type I,Prealbumin Thyroxine-binding,Senile systemic amyloidosis,Thyroxine binding prealbumin,Transthyretin,TTR,TTHY,TTR protein,Transthyretin (TTR) is a highly conserved homotetremric protein that is synthesized in the liver and choroid plexus of the brain. TTR wasoriginally discovered as a protein found in human plasma and cerebrospinal fluid (CSF). TTR transports thyroid hormones (TH) and retinol bybinding to retinol-binding protein. Although TTR is synthesized in the liver and choroid plexus, TTR is detected in blood plasma andcerebrospinal fluid migrating as monomers, dimers, and tetramers. Beyond its function as a carrier protein of TH and retinol in plasma andCSF, several additional TTR functions have been described, including proteolytic cleavage of specific substrates like apolipoprotein,neuropeptide Y (NPY), and APP. These neuronal substrates suggest a functional role for TTR in the central nervous system. Consistent witha CNS function, TTR null mice exhibit memory impairments and altered sensorimotor behavior). TTR may also be linked to neurodegenerativedisease: TTR levels in Alzheimer's disease (AD) patients are negatively correlated with disease progression, and a protective role for TTR, atleast in AD mouse models, has been described. TTR itself may play a more direct role in disease as gain-of-function mutations in TTR causethe protein to misfold and aggregate into amyloid fibrils, contributing to autosomal dominant hereditary amyloidosis in diseases such as familialamyloid polyneuropathy, familial amyloid cardiomyopathy, and familial leptomeningeal amyloidosis. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 16 kDa

Observed MW: 35 kDa The actual band is not consistent with the expectation.

UniProt: P02766

Pathways: Hormone Transport