PD-1 antibody

Catalog No. ABIN7828853

The Rat Monoclonal anti-PD-1 antibody is suitable to detect PD-1 in samples from Mouse. It has been validated for FACS.

Quick Overview for PD-1 antibody (ABIN7828853)

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This PD-1 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: RMP1-14

Product Details anti-PD-1 Antibody

Purpose: AF/LE Purified Anti-Mouse CD279 Antibody[RMP1-14]

Purification: >98%, Protein A/G purified

Purity: >98 %

Immunogen: Recombinant Human CD279 protein

Isotype: IgG2a, kappa

Application Details

Application Notes: FCM 2 μg/mL(0.5x106-1x106 cells)

Restrictions: For Research Use only

Handling

Concentration: ≥ 1 mg/mL

Buffer: Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.

Preservative: Without preservative

Handling Advice: This preparation contains no preservatives, thus it should be handled under aseptic conditions

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Expiry Date: 12 months

Target Details for PD-1

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Alternative Name: CD279

Background: CD279 antigen,hPD 1,hPD l,Ly101,PD 1,Pdc1,PDCD 1,Programmed cell death 1 protein,Protein PD 1,Protein PD-1,Systemic lupus erythematosus susceptibility 2,hPD,mPD,Programmed Death,Programmed cell death,Programmed cell death protein,PDCD,hSLE,SLEB,PD-1,CD279,hPD-1,hPD-l,hSLE1,mPD-1,Programmed cell death 1,Programmed cell death protein 1,Programmed Death-1,SLEB2,Pd1,Pdcd1,Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion. Cat.No. Product Name Clone No. E-AB-F11310 AF/LE Purified Anti-Mouse CD279/PD-1 Antibody[29F.1A12] 29F.1A12 IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

UniProt: Q02242

Pathways: Cancer Immune Checkpoints