IL4 Receptor antibody (AA 201-300)

Catalog No. ABIN740565

This anti-IL4 Receptor antibody is a Rabbit Polyclonal antibody detecting IL4 Receptor in WB, ELISA, FACS, ICC, IF (p) and IHC (p). Suitable for Human and Mouse. This Primary Antibody has been cited in 2+ publications.

Quick Overview for IL4 Receptor antibody (AA 201-300) (ABIN740565)

Target: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL4 Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-IL4 Receptor Antibody

Binding Specificity: AA 201-300

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human IL4R

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-IL4 Receptor antibody (ABIN740565)

Danelli, Frossi, Gri, Mion, Guarnotta, Bongiovanni, Tripodo, Mariuzzi, Marzinotto, Rigoni, Blank, Colombo, Pucillo: "Mast cells boost myeloid-derived suppressor cell activity and contribute to the development of tumor-favoring microenvironment." in: Cancer immunology research, Vol. 3, Issue 1, pp. 85-95, (2015) (PubMed).

Target Details for IL4 Receptor

Target: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Alternative Name: IL4R

Background:

Synonyms: CD124, IL4RA, IL-4RA, Interleukin-4 receptor subunit alpha, IL-4 receptor subunit alpha, IL-4R subunit alpha, IL-4R-alpha, IL4R, 582J2.1

Background: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.

Gene ID: 3566

UniProt: P24394

Pathways: JAK-STAT Signaling, Positive Regulation of Immune Effector Process