DDB1 antibody (AA 951-1140)

Catalog No. ABIN742455

This anti-DDB1 antibody is a Rabbit Polyclonal antibody detecting DDB1 in ELISA, IHC (p), IHC (fro), IF (cc) and IF (p). Suitable for Human.

Quick Overview for DDB1 antibody (AA 951-1140) (ABIN742455)

Target: DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DDB1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-DDB1 Antibody

Binding Specificity: AA 951-1140

Predicted Reactivity: Human,Mouse,Rat,Cow,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DDB1

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for DDB1

Target: DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))

Alternative Name: DDB1

Background:

Synonyms: DNA damage-binding protein 1, DDB1, DDB-1, ,Damage specic DNA binding protein 1, DDB 1, DDB p127 subunit, DDBa, DNA damage binding protein 1, UV damaged DNA binding factor, UV damaged DNA binding protein 1, UV DDB 1, UV-DDB1, X associated protein 1, XAP 1, XAP1, Xeroderma pigmentosum group E complementing protein, XPCE, XPE, XPE binding factor, XPE-BF.

Background: This gene encodes the large subunit of DNA damage-binding protein which is a heterodimer composed of a large and a small subunit. This protein functions in nucleotide-excision repair. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. [provided by RefSeq].

Gene ID: 1642

Pathways: DNA Damage Repair