Recombinant MUC4 antibody (AA 1729-1860)

Catalog No. ABIN7865533

The Rabbit Monoclonal anti-MUC4 antibody is suitable to detect MUC4 in samples from Human. It has been validated for IHC.

Quick Overview for Recombinant MUC4 antibody (AA 1729-1860) (ABIN7865533)

Target: MUC4 (Mucin 4, Cell Surface Associated (MUC4))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MUC4 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: MUC4-8660R

Product Details anti-MUC4 Antibody

Binding Specificity: AA 1729-1860

Expression System: CHO Cells

Purpose: Recombinant MUC4 (Mucin 4 / Gastric Mucin) Antibody

Specificity: The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. MUC-4 transcripts have been detected in normal respiratory epithelium and lung. MUC-4 is a very specific (100 % ) and sensitive (90 %) marker of lung adenocarcinomas and is negative for mesotheliomas. Reportedly, MUC-4 expression in invasive ductal carcinoma of the pancreas is an independent factor for poor prognosis.

Purification: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogen: Recombinant fragment (around aa 1729-1860) of human MUC4 protein (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for MUC4

Target: MUC4 (Mucin 4, Cell Surface Associated (MUC4))

Alternative Name: MUC4 Mucin 4

Background:

Ascites sialoglycoprotein 1 / 2, ASGP, ASGP-1, ASGP-2, MUC-4, MUC4, Mucin 4 cell surface associated, Mucin 4 tracheobronchial, Mucin-4 beta chain, Pancreatic adenocarcinoma mucin, Testis mucin, Tracheobronchial mucin

Human stomach, colon or esophagus.

Molecular Weight: 235kDa

Gene ID: 4585, 369646

UniProt: Q99102

Pathways: Regulation of Leukocyte Mediated Immunity