Recombinant HSPH1 antibody (C-Term)

Catalog No. ABIN7865495

This Mouse Monoclonal antibody specifically detects HSPH1 in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for Recombinant HSPH1 antibody (C-Term) (ABIN7865495)

Target: HSPH1 (Heat Shock 105kDa/110kDa Protein 1 (HSPH1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HSPH1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: R58F12

Product Details anti-HSPH1 Antibody

Binding Specificity: C-Term

Expression System: CHO Cells

Purpose: Recombinant Heat Shock Protein 105 kDa / HSP105 (Basaloid Skin Tumor Marker) Antibody

Specificity: Heat shock protein (HSP) 105 exists as two isoforms, alpha and beta which belong to the HSP105/HSP110 protein family. HSP105 acts as both a chaperone to prevent thermal aggregation of proteins and as a regulator of mammalian cells. The HSP105 isoforms are found in the cytoplasm but not in the nucleoli under non-stressed and stressed conditions. In rodents, HSP105 isoforms are moderately expressed in the adrenal glands, spleen, liver and heart and both are markedly increased after heat shock. In the testis, HSP105 is specifically localized in the cytoplasm of germ cells and may translocate to the nucleus after heat shock. The most abundant expression occurs in the brain with nuclear and cytoplasmic expression in nearly all neurones, oligodendrocytes, microglia and astrocytes. Increased expression during embryogenesis suggests that HSP105 may have an important role during mouse embryo development.

Purification: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogen: Prokaryotic recombinant protein of 31 kD corresponding to the C-terminus of the heat shock protein 105 molecule

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for HSPH1

Target: HSPH1 (Heat Shock 105kDa/110kDa Protein 1 (HSPH1))

Alternative Name: Heat Shock Protein 105 kDa

Background:

HSP105, HSP110, KIAA0201, HSPH1, Heat shock protein 105 kDa, Antigen NY-CO-25, Heat shock 110 kDa protein, Heat shock protein family H member 1

Human brain or testis.

Molecular Weight: 105kDa

Gene ID: 10808

UniProt: Q92598