Recombinant SV2A antibody (Cytoplasmic Domain, N-Term)

Catalog No. ABIN7865492

The Mouse Monoclonal anti-SV2A antibody (Clone r15E11) (ABIN7865492) specifically detects SV2A in IHC. The antibody is reactive with Human samples.

Quick Overview for Recombinant SV2A antibody (Cytoplasmic Domain, N-Term) (ABIN7865492)

Target: SV2A (Synaptic Vesicle Glycoprotein 2A (SV2A))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SV2A antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: R15E11

Product Details anti-SV2A Antibody

Binding Specificity: Cytoplasmic Domain, N-Term

Expression System: CHO Cells

Purpose: Recombinant Synaptic Vesicle Protein 2 (SV2) (Marker of Neuroendocrine Cells) Antibody

Specificity: Synaptic vesicle protein 2 (SV2) is an integral membrane glycoprotein. It is required for normal neurotransmission and may play a role in the regulation of calcium-stimulated exocytosis. SV2 exists in three forms, SV2A, SV2B and SV2C, each containing 12 transmembrane spanning regions. SV2 proteins are among the most abundant and conserved components of synaptic vesicles in vertebrates. They are present on all small synaptic vesicles independent of transmitter type. SV2A and SV2B are widely distributed in the nervous system, whereas SV2C is only observed in a small number of neurons in a few areas of the brain. SV2A is expressed at the highest levels in subcortical regions, whereas the highest level of expression of SV2B is in the cortex and hippocampus. SV2 is expressed on secretory vesicles of neuroendocrine cells in the GI tract, pancreas, anterior pituitary gland, thyroid, parathyroid and adrenal medulla and also in exocrine chief cells of gastric mucosa.

Purification: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogen: Prokaryotic recombinant protein corresponding to the N-terminal cytoplasmic domain of the human synaptic vesicle 2A molecule which shares some regions of homology with the SV2B molecule

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for SV2A

Target: SV2A (Synaptic Vesicle Glycoprotein 2A (SV2A))

Alternative Name: Synaptic Vesicle Protein 2

Background:

KIAA0736 | PSEC0174 | SV2A | Synaptic vesicle glycoprotein 2A

Human brain.

Molecular Weight: 93kDa

Gene ID: 9900

UniProt: Q7L0J3