Recombinant CD40 antibody

Catalog No. ABIN7857762

The Mouse Monoclonal anti-CD40 antibody is suitable to detect CD40 in samples from Human. It has been validated for WB and IHC.

Quick Overview for Recombinant CD40 antibody (ABIN7857762)

Target: CD40

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD40 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: R11E9

Product Details anti-CD40 Antibody

Expression System: CHO Cells

Purpose: Recombinant CD40 / TNFRSF5 Antibody

Specificity: The CD40 antigen is a single chain glycoprotein with a calculated molecular weight of 27 kD. It is known to be a member of the tumor necrosis factor/nerve growth factor superfamily and shows a significant homology to the Hodgkin,Ä111s disease-associated antigen, CD30. The precise function of the CD40 antigen is unknown, but it appears to be involved in the transduction of regulatory signals for cellular functions such as B cell proliferation and differentiation. It is also important in the prevention of apoptosis of germinal centre B cells. The CD40 antigen is found on mature B cells (except plasma cells), interdigitating reticulum cells and follicular dendritic cells.

Purification: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogen: Prokaryotic recombinant fusion protein corresponding to the entire external domain of the CD40 molecule

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for CD40

Target: CD40

Alternative Name: CD40

Background:

TNFRSF5

Human spleen, lymph node or tonsil.

Molecular Weight: 43kDa

Gene ID: 958, 472860

UniProt: P25942

Pathways: NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints