Recombinant Uroplakin 2 antibody (AA 36-51)

Catalog No. ABIN7858042

The Rabbit Monoclonal anti-Uroplakin 2 antibody (Clone UPK2-13348R) (ABIN7858042) specifically detects Uroplakin 2 in IHC. The antibody is reactive with Human samples.

Quick Overview for Recombinant Uroplakin 2 antibody (AA 36-51) (ABIN7858042)

Target: Uroplakin 2 (UPK2)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Uroplakin 2 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: UPK2-13348R

Product Details anti-Uroplakin 2 Antibody

Binding Specificity: AA 36-51

Purpose: Recombinant Uroplakin II (UPK2) (Urothelial Differentiation Marker) Antibody

Specificity: Uroplakin II (UPII) is a 15- kDa protein comprising urothelial plaques, which fortify the urothelial barrier. It is a highly specific marker for tumors of urothelial origin, particularly urothelial carcinoma (UC). UPII messenger RNA has been detected in the tissue and blood of UC patients. Immunohistochemistry utilizing UPII antibodies, such as UPK2/13669R, exhibits high specificity and increased sensitivity for urothelial carcinoma compared to UPIII antibodies. UPII immunohistochemistry is valuable for differentiating urothelial carcinoma from other malignancies, including prostate adenocarcinoma or metastatic breast carcinoma. It has also shown promise for detecting micrometastases of bladder cancer. UPII expression is found in various UC subtypes like micro-papillary, plasmacytoid, and sarcomatoid variants.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A.

Immunogen: Recombinant fragment (around aa 36-51) of human Uroplakin 2 (UPK2) protein (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for Uroplakin 2

Target: Uroplakin 2 (UPK2)

Alternative Name: Uroplakin II

Background:

UP2, UPII

Urinary bladder.

Molecular Weight: 195kDa

Gene ID: 7379

UniProt: O00526