NFKBIB antibody (pSer23) (Cy3)

Catalog No. ABIN742631

The Rabbit Polyclonal anti-NFKBIB antibody has been validated for WB, IF (cc) and IF (p). It is suitable to detect NFKBIB in samples from Human.

Quick Overview for NFKBIB antibody (pSer23) (Cy3) (ABIN742631)

Target: NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NFKBIB antibody is conjugated to Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-NFKBIB Antibody (Cy3)

Binding Specificity: pSer23

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human NFKBIB around the phosphorylation site of Ser23

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for NFKBIB

Target: NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))

Alternative Name: IKB beta

Background:

Synonyms: IKB beta Ser23, IKB beta S23, p-IKB beta Ser23, p-IKB beta S23, NFKBIBSer23, NFKBIBphospho S23, IkB-betaSer22, IkB beta, NF-kappa-B inhibitor beta, IKB beta, NF-kappa-BIB, TRIP-9, I-kappa-B-beta, IkappaBbeta, IkB-beta, IkB-B, Thyroid receptor-interacting protein 9, TR-interacting protein 9, NFKBIB, IKBB.

Background: The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011].

Gene ID: 4793

Pathways: NF-kappaB Signaling, Activation of Innate immune Response, Maintenance of Protein Location, Toll-Like Receptors Cascades