Recombinant Glucagon antibody (AA 1-100)

Catalog No. ABIN7865423

The Rabbit Monoclonal anti-Glucagon antibody (Clone GCG-13090R) (ABIN7865423) specifically detects Glucagon in IHC. The antibody is reactive with Human samples.

Quick Overview for Recombinant Glucagon antibody (AA 1-100) (ABIN7865423)

Target: Glucagon (GCG)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Glucagon antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: GCG-13090R

Product Details anti-Glucagon Antibody

Binding Specificity: AA 1-100

Purpose: Recombinant Glucagon (Marker of Glucagonoma) Antibody

Specificity: Glucagon is a pancreatic hormone that functions as an antagonist to Insulin, stimulating the conversion of glycogen to glucose and increasing blood sugar levels. Glucagon-like peptide-1 (GLP-1), Glucagon-like peptide-2 (GLP-2), VIP (vasoactive intestinal peptide) and PACAP (pituitary adenylate cyclase activating polypeptide) are members of the Glucagon family of hormones. GLP-1 functions as a transmitter in the central nervous system, inhibiting feeding and drinking behavior, whereas GLP-2 is a stimulator of intestinal epithelial growth. VIP causes vasodilation resulting in the lowering of blood pressure. PACAP is abundant in the hypothalamus and has been shown to increase the synthesis of several hormones, including growth hormone. Glucagon antibody detects glucagon-secreting cells and tumors such as glucagonomas, of which approximately 80 % are malignant.

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1-100) of human GCG protein (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for Glucagon

Target: Glucagon (GCG)

Alternative Name: Glucagon

Background:

GLP1, GLP2, GRPP, GLP-1

Human pancreas.

Molecular Weight: 19kDa (Proglucagon), 3kDa (Glucagon)

Gene ID: 2641

UniProt: P01275

Pathways: Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, cAMP Metabolic Process, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Negative Regulation of intrinsic apoptotic Signaling