PVALB antibody (AA 1-110)

Catalog No. ABIN7864979

The Mouse Monoclonal anti-PVALB antibody (Clone PVALB-7601) (ABIN7864979) specifically detects PVALB in IHC. The antibody is reactive with Human samples.

Quick Overview for PVALB antibody (AA 1-110) (ABIN7864979)

Target: PVALB (Parvalbumin (PVALB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PVALB antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: PVALB-7601

Product Details anti-PVALB Antibody

Binding Specificity: AA 1-110

Purpose: Parvalbumin / PVALB Antibody

Specificity: The family of EF-hand type Ca2+-binding proteins includes calbindin (previously designated vitamin D-dependent Ca2+-binding protein), S-100± and ≤, calgranulins A (also designated MRP8), B (also designated MRP14) and C (S-100 like proteins) and the parvalbumin family members, including parvalbumin ± and parvalbumin ≤, also designated oncomodulin (OCM). Structurally and evolutionarily conserved, parvalbumin ± and OCM proteins are distinct in expression and function. Parvalbumin ±, also designated parvalbumin (PV), is most abundantly expressed in fast-contracting muscles with lower expression levels in brain and some endocrine tissues, including kidney and parathyroid. Research indicates that parvalbumin ± plays a significant role in muscle relaxation. OCM was originally thought to have expression restricted to neoplastic tissues, early embryonic cells and certain tumor cell lines. Recent research shows that OCM is also expressed and secreted by macrophages where, in the retina it binds to retinal ganglion cells (RGCs) and functions to promote axon regeneration. OCM has also been detected in the auditory sensory cells of the organ of Corti in mammals. In humans, two different loci on chromosome 7 have been identified as OCM and OCM-like (LOC4951). These genes encode proteins 109 amino acids in length which share 99 % sequence identity.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1-110) of human PVALB protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for PVALB

Target: PVALB (Parvalbumin (PVALB))

Alternative Name: Parvalbumin

Background:

PVALB, Parvalbumin alpha

Human brain or kidney.

Molecular Weight: 12kDa

Gene ID: 5816, 295449

UniProt: P20472