IL-31 antibody (AA 1-164)

Catalog No. ABIN7858300

The Mouse Monoclonal anti-IL-31 antibody (Clone IL31-7333) (ABIN7858300) specifically detects IL-31 in IHC. The antibody is reactive with Human samples.

Quick Overview for IL-31 antibody (AA 1-164) (ABIN7858300)

Target: IL-31 (IL31) (Interleukin 31 (IL31))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL-31 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: IL31-7333

Product Details anti-IL-31 Antibody

Binding Specificity: AA 1-164

Purpose: Interleukin-31 / IL-33 Antibody

Specificity: IL-31 is a T cell cytokine that is preferentially produced by T helper type 2 cells. IL-31 signals through a heterodimeric receptor composed of the IL-31 receptor (IL-31R) and the oncostatin M receptor (OSM). This receptor complex recruits JAK1, JAK2, Stat1, Stat3 and Stat5 signaling pathways, as well as the PI3 kinase/AKT cascade. SHP-2 and Shc adapter molecules are also recruited and contribute to an increased activation of the MAP kinase pathway in response to IL-31. Overexpression of IL-31 in mice results in pruritus and skin dermatitis resembling human atopic dermatitis (AD). Comparisons between skin from patients with AD and healthy skin showed IL-31R expression at higher levels on epidermal keratinocytes in AD samples. Infiltrating cells, more numerous in skin from patients with AD compared with that of healthy individuals, expressed IL-31 mRNA. IL-31 may participate in the cause of itch sensation and promote scratching behavior in NC/Nga mice with atopic dermatitis, and may represent a novel target for antipruritic drug development.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1-164) of human IL31 protein (exact sequence is proprietary)

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for IL-31

Target: IL-31 (IL31) (Interleukin 31 (IL31))

Alternative Name: Interleukin-31

Background:

IL-31, Interleukin 31

bone marrow|colon|Detected at low levels in testis|kidney|skeletal muscle|small intestine and trachea.|thymus

Molecular Weight: 18 kDa

Gene ID: 386653, 569071

UniProt: Q6EBC2