Cofilin 2 antibody (AA 1-166)

Catalog No. ABIN7865261

This Mouse Monoclonal antibody specifically detects Cofilin 2 . It exhibits reactivity toward Human.

Quick Overview for Cofilin 2 antibody (AA 1-166) (ABIN7865261)

Target: Cofilin 2 (CFL2)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cofilin 2 antibody is un-conjugated

Application: Please inquire

Clone: CFL2-9963

Product Details anti-Cofilin 2 Antibody

Binding Specificity: AA 1-166

Purpose: CFL2 / NEM7 Antibody

Specificity: Cofilin is ubiquitously expressed in eukaryotic cells where it binds to Actin, thereby regulating the rapid cycling of Actin assembly and disassembly essential for cellular viability. Cofilin is a low molecular weight protein that binds to filamentous (F) Actin by bridging two longitudinally associated Actin subunits changing the F-Actin filament twist. This process is allowed by the dephosphorylation of Cofilin Ser-3 by factors such as opsonized zymosan. Lim kinase 1, a serine kinase, phosphorylates Cofilin and renders it unable to bind and depolymerise F-Actin.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1-166) of human CFL2 protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Application Details

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for Cofilin 2

Target: Cofilin 2 (CFL2)

Alternative Name: CFL2

Background: NEM7

Molecular Weight: 19-21kDa

Gene ID: 1073, 180141

UniProt: Q9Y281

Pathways: Caspase Cascade in Apoptosis