GCET2 antibody (AA 1-200)

Catalog No. ABIN7858464

The Mouse Monoclonal anti-GCET2 antibody is suitable to detect GCET2 in samples from Human. It has been validated for IHC.

Quick Overview for GCET2 antibody (AA 1-200) (ABIN7858464)

Target: GCET2 (Germinal Center Expressed Transcript 2 (GCET2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GCET2 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: HGAL-2834

Product Details anti-GCET2 Antibody

Binding Specificity: AA 1-200

Purpose: HGAL (Human Germinal Center Associated Lymphoma Marker) Antibody

Specificity: Recognizes a protein of ??? kDa, which is identified as HGAL. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. 79oΩ HGAL is specifically expressed in germinal center B-cells, but is absent in mantle and marginal zone B-cells and in the inter-follicular and para-cortical regions in normal tonsils and lymph nodes. Its high degree of specificity for germinal center B-cells makes anti-HGAL an ideal marker for the detection of germinal center-derived B-cell lymphomas. HGAL expression has been used to help elucidate nodal marginal zone lymphoma (NMZL) from cases of diffuse follicle center lymphoma. Additionally, HGAL expression was shown to correlate with survival in patients with diffuse large B-cell lymphoma (DLBCL).

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1-200) of human HGAL protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for GCET2

Target: GCET2 (Germinal Center Expressed Transcript 2 (GCET2))

Alternative Name: HGAL

Background:

GCAT2, GCET2 germinal center expressed transcript 2, Germinal center associated lymphoma (hGAL), Germinal center B-cell-expressed transcript 2 protein, Germinal center-associated signaling and motility protein

Daudi|Raji or U266 cells. Human lymphocytes. Human lymph node|tonsil or testis.

Molecular Weight: 21kDa

Gene ID: 257144, 49614

UniProt: Q8N6F7