IL20RA antibody (AA 1-200)

Catalog No. ABIN7858559

This Mouse Monoclonal antibody specifically detects IL20RA in IHC. It exhibits reactivity toward Human.

Quick Overview for IL20RA antibody (AA 1-200) (ABIN7858559)

Target: IL20RA (Interleukin 20 Receptor alpha (IL20RA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL20RA antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: IL20RA-1752

Product Details anti-IL20RA Antibody

Binding Specificity: AA 1-200

Purpose: IL20RA (Interleukin 20 Receptor Subunit Alpha) Antibody

Specificity: The class II cytokine receptor family includes 12 members, 11 of which combine as various heterodimers to transduce signals across the cellular membrane for 27 cytokines. These cytokines are divided into four structurally related groups: six cytokines of the IL-10 family, 17 type I IFNs, one type II IFN and three IFN-l. IL-20 is a member of the IL-10 family of cytokines that has been shown to be upregulated in psoriatic skin. The receptor for IL-20 (IL-20R) exists as a dimer consisting of IL-20Ra and IL-20Rb. IL-20R also functions as a receptor for IL-19, IL-24 and IL-26. It is highly expressed in skin, brain and testis. IL-20, IL-20Ra and IL-20Rb all have higher expression levels in psoriatic lesional (LS) skin than in nonlesional (NL) skin, suggesting a role for these proteins as potential therapeutic targets. IL-20 can induce signal transducer and activator of transcription (Stat) activation through IL-20R.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1-200) of human IL20RA protein (exact sequence is proprietary)

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for IL20RA

Target: IL20RA (Interleukin 20 Receptor alpha (IL20RA))

Alternative Name: IL20RA

Background:

class II cytokine receptor ZCYTOR7, CRF2 8, Cytokine receptor class II member 8, Cytokine receptor family 2 member 8, IL 20R1, IL-20 receptor subunit alpha, IL-20R1, IL20 Receptor alpha, Interleukin 20 receptor alpha chain,

brain or psoriatic skin.|Human skin|testis

Molecular Weight: 90-100kDa

Gene ID: 53832, 445868

UniProt: Q9UHF4