IL22RA2 antibody (AA 1-200)

Catalog No. ABIN7858562

This Mouse Monoclonal antibody specifically detects IL22RA2 in IHC. It exhibits reactivity toward Human.

Quick Overview for IL22RA2 antibody (AA 1-200) (ABIN7858562)

Target: IL22RA2 (Interleukin 22 Receptor, alpha 2 (IL22RA2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL22RA2 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: IL22RA2-7291

Product Details anti-IL22RA2 Antibody

Binding Specificity: AA 1-200

Purpose: IL22RA2 Antibody

Specificity: IL-22R±2 (Interleukin-22 receptor ±2 chain), also known as IL-22 binding protein (IL-22BP), cytokine receptor family class II member 10 (CRF2-10) or CRF2- soluble 1 (CRF2-S1), is a soluble, nonsignaling single chain receptor for IL-22. It is highly expressed in intestine and lymph nodes and is also found in spleen, kidney and liver. IL-22R±2 has a cytokine-binding domain that contains two FnIII domains. Its affinity for IL-22 is 4- to 10-fold higher than that of the membrane-bound IL-22 receptor, however it has a dissociation rate up to 20 times lower. By binding to IL-22, IL-22R±2 prevents the binding to the IL-22 membrane-bound receptor and therefore inhibits IL-22 signaling. This suggests that IL-22R±2 may be important in regulating inflammatory responses. In addition, IL-22R±2 can be induced by lipopolysaccharides (LPSs).

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1-200) of human IL22RA2 protein (exact sequence is proprietary)

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for IL22RA2

Target: IL22RA2 (Interleukin 22 Receptor, alpha 2 (IL22RA2))

Alternative Name: IL22RA2

Background:

IL 22BP, IL22RA2, Class II cytokine receptor, CRF2-10, CRF2-S1, CRF2X, Cytokine receptor class-II member 10, Cytokine receptor family type 2 soluble 1, IL-22 receptor subunit alpha-2, IL-22BP, IL-22R-alpha-2, Interleukin 22 binding protein, Interleukin 22 Receptor alpha 2, Class II cytokine receptor

carcinoma or liver.|colon|Human tonsil

Molecular Weight: 27 kDa

Gene ID: 116379, 126891

UniProt: Q969J5