Kallikrein 4 antibody (AA 1-200)

Catalog No. ABIN7858590

The Mouse Monoclonal anti-Kallikrein 4 antibody is suitable to detect Kallikrein 4 in samples from Human. It has been validated for IHC.

Quick Overview for Kallikrein 4 antibody (AA 1-200) (ABIN7858590)

Target: Kallikrein 4 (KLK4) (Kallikrein-Related Peptidase 4 (KLK4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Kallikrein 4 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: KLK4-8941

Product Details anti-Kallikrein 4 Antibody

Binding Specificity: AA 1-200

Purpose: KLK4 / Kallikrein related peptidase 4 Antibody

Specificity: Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes. Human pancreatic/renal KLK encodes for the KLK1 enzyme, which is involved in post-translational processing of polypeptide precursors. The function of the other members of KLK gene family is still currently unknown, but evidence suggests that many KLKs are implicated in carcinogenesis. The human KLK gene family consists of 15 serine proteases. The human KLK genes are clustered on chromosome 19q13. Unlike other kalllikreins, the KLK4-15 encoded proteases are less related and do not contain a conventional KLK loop. Clusters of genes exhibit high prostatic (KLK2-4, KLK15) or pancreatic (KLK6-13) expression. KLK2 is also known as glandular kallikrein 2, tissue kallikrein, or HGK-1 and KLK3 is known as prostate-specific antigen (PSA). Both KLK2 and KLK3 have important applications in prostate cancer and breast cancer diagnostics. Many of the KLKs are regulated by steroid hormones and a few of them, specifically KLK3, KLK6 and KLK10, are known to be downregulated in breast and other cancers. KLK4 expression is abundant in skin, mammary gland and testis.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment of human KLK4 protein (around aa 1-200) (exact sequence is proprietary)

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for Kallikrein 4

Target: Kallikrein 4 (KLK4) (Kallikrein-Related Peptidase 4 (KLK4))

Alternative Name: KLK4

Background:

7S nerve growth factor alpha chain, AI2A1, Alpha-NGF, Androgen-regulated message 1, ARM1, EC 3.4.21.-, EMSP1, Enamel Matrix Serine Protease 1, HK4, Kallikrein 4, Kallikrein L1, Kallikrein like protein 1, Kallikrein related-peptidase 4 (prostase, enamel matrix, prostate), KLK-L1, KLK4, Protease Serine 17, PRSS17, PSTS, Serine protease 17

Human skin tissue (IHC). MCF-7 cell lysates.

Molecular Weight: 28-37kDa

Gene ID: 9622, 218366

UniProt: Q9Y5K2

Pathways: Complement System