KNG1 antibody (AA 1-200)

Catalog No. ABIN7864818

The Mouse Monoclonal anti-KNG1 antibody (Clone KNG1-7424) (ABIN7864818) specifically detects KNG1 in IHC. The antibody is reactive with Human samples.

Quick Overview for KNG1 antibody (AA 1-200) (ABIN7864818)

Target: KNG1 (Kininogen 1 (KNG1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This KNG1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: KNG1-7424

Product Details anti-KNG1 Antibody

Binding Specificity: AA 1-200

Purpose: KNG1 / Kininogen 1 (KNG1-Heavy chain) Antibody

Specificity: Kininogen is a 644 amino acid precursor protein that is expressed by the KNG1 gene and is secreted into blood plasma. Due to alternative splicing events, several Kininogen protein derivatives exist, including Kininogen LC and Kininogen HC, both of which are produced from the Kininogen precursor and exhibit different functions throughout the cell. Kininogen HC plays an important role in blood coagulation by helping to ensure that prekallikrein and Factor XI (both of which are involved in blood coagulation) are properly situated for interaction with Factor XII. Kininogen HC releases a smaller, active protein known as bradykinin, which plays a role in smooth muscle contraction, induction of hypotension, regulation of blood glucose levels, stimulation of nociceptors and overall mediation of inflammatory responses throughout the cell. In contrast to Kininogen HC, which is involved in blood clotting, Kininogen LC is primarily associated with inhibition of thrombocyte aggregation and also functions as a strong inhibitor of cysteine proteinases.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1-200) of human KNG1 protein (exact sequence is proprietary)

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for KNG1

Target: KNG1 (Kininogen 1 (KNG1))

Alternative Name: KNG1

Background:

Alpha-2-thiol proteinase inhibitor, BDK, BK, Bradykinin included, Fitzgerald factor, FLAUJEAC FACTOR, HMW kininogen, Ile-Ser-Bradykinin, Kallidin I, Kallidin II, LMW growth-promoting factor, Williams-Fitzgerald-Flaujeac factor

Distinct positivity in plasma and in several cases extracellular matrix along with cytoplasmic expression in kidney.

Molecular Weight: 64 kDa (heavy chain), 53 kDa (light chain)

Gene ID: 3827, 77741

Pathways: ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process