Recombinant PMS2 antibody (AA 1-200)

Catalog No. ABIN7858658

This Rabbit Monoclonal antibody specifically detects PMS2 in IHC. It exhibits reactivity toward Human.

Quick Overview for Recombinant PMS2 antibody (AA 1-200) (ABIN7858658)

Target: PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PMS2 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: PMS2-8374R

Product Details anti-PMS2 Antibody

Binding Specificity: AA 1-200

Purpose: Recombinant PMS2 (Postmeiotic Segregation Increased 2) Antibody

Specificity: PMS2 is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Defects in PMS2 are the cause of hereditary non-polyposis colorectal cancer type 4 (HNPCC4). Mutations in more than one gene locus can be involved alone or in combination in the production of the HNPCC phenotype (also called Lynch syndrome). Most families with clinically recognized HNPCC have mutations in either MLH1 or MSH2 genes. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (CRC) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world, and accounts for 15 % of all colon cancers. Defects in PMS2 are a cause of mismatch repair cancer syndrome (MMRCS), also known as Turcot syndrome or brain tumor-polyposis syndrome 1 (BTPS1). MMRCS is an autosomal dominant disorder characterized by malignant tumors of the brain associated with multiple colorectal adenomas. Skin features include sebaceous cysts, hyperpigmented and cafe au lait spots.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1-200) of human PMS2 protein (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for PMS2

Target: PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))

Alternative Name: PMS2

Background:

DNA mismatch repair protein PMS2, hereditary non-polyposis colorectal cancer type 4 (HNPCC4), Mismatch repair gene PMSL2, PMS1 protein homolog 2, postmeiotic segregation increased 2 (S. cerevisiae), PMS2CL

Human colon carcinoma.

Molecular Weight: 96kDa

Gene ID: 5395, 632637

UniProt: P54278

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response