HMMR antibody (AA 1-250)

Catalog No. ABIN7865052

This Mouse Monoclonal antibody specifically detects HMMR in IHC. It exhibits reactivity toward Human.

Quick Overview for HMMR antibody (AA 1-250) (ABIN7865052)

Target: HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HMMR antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: HMMR-8021

Product Details anti-HMMR Antibody

Binding Specificity: AA 1-250

Purpose: CD168 / RHAMM Antibody

Specificity: Hyaluronic acid (HA) is a nonsulfated glycosaminoglycan that regulates cell adhesion and migration. HA effects are mediated through two receptors, CD44 (also designated HCAM) and the receptor of hyaluronic acid mediated motility (RHAMM). RHAMM, also designated intracellular hyaluronic acid binding protein (IHABP) and CD168, is a matrix receptor, which is linked to the plasma membrane by a GPI anchor and regulates cell motility. RHAMM expression is upregulated in malignant lymphoid tissues and is subsequently implicated in tumor progression and metastasis formation, as well as signal transduction. Although still unclear, RHAMM is thought to exist as several isoforms ranging in size. A variant isoform, designated v4, is a protein that when over-expressed, is thought to be the cause of transformation and metastasis formation in fibroblasts.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1-250) of human HMMR protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for HMMR

Target: HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))

Alternative Name: CD168

Background:

CD168, CD168 antigen, HMMR, Hyaluronan-mediated motility receptor (RHAMM), IHABP, Intracellular hyaluronic acid-binding protein, Receptor for hyaluronan-mediated motility

breast cancer or placenta.|Human breast

Molecular Weight: 85-90kDa

Gene ID: 3161, 728200

UniProt: O75330

Pathways: Glycosaminoglycan Metabolic Process