KCNIP2 antibody (AA 1-270)

Catalog No. ABIN7864996

The Mouse Monoclonal anti-KCNIP2 antibody (Clone KCNIP2-7588) (ABIN7864996) specifically detects KCNIP2 in IHC. The antibody is reactive with Human samples.

Quick Overview for KCNIP2 antibody (AA 1-270) (ABIN7864996)

Target: KCNIP2 (Kv Channel Interacting Protein 2 (KCNIP2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This KCNIP2 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: KCNIP2-7588

Product Details anti-KCNIP2 Antibody

Binding Specificity: AA 1-270

Purpose: KCNIP2 / KCHIP2 Antibody

Specificity: In the brain and heart, rapidly inactivating (A-type) voltage-gated potassium (Kv) currents control the excitability of neurons and cardiac myocytes. KChIPs are Kv channel-interacting proteins that bind to the cytoplasmic amino termini of Kv4±-subunits and are integral components of native Kv4 channel complexes. KChIP family members include KChIP1 expressed in brain, KChIP2 expressed in heart, brain, and lung, and KChIP3 (previously identified as calsenilin) expressed in brain and testis. In rat brain, KChIP1 colocalizes with Kv4.3 in granule cells and KChIP2 colocalizes with Kv4.2 in both neocoritcal and subcortical structures. The KChIPs are members of the recoverin/neuronal calcium sensor-1 subfamily of calcium-binding proteins and show 99 % nucleotide homology to DREAM, suggesting that KChIPs may have activity beyond modulation of Kv4 channels.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1-270) of human KCNIP2 protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for KCNIP2

Target: KCNIP2 (Kv Channel Interacting Protein 2 (KCNIP2))

Alternative Name: KCNIP2

Background:

A type potassium channel modulatory protein 2, Cardiac voltage gated potassium channel modulatory subunit, DKFZp566L1246, KChIP2, Kcnip2, Kv channel interacting protein 2, Potassium channel interacting protein 2

Human brain.

Molecular Weight: 27-36kDa

Gene ID: 30819, 97044

UniProt: Q9NS61