TFPI2 antibody (AA 100-235)

Catalog No. ABIN7865306

This Mouse Monoclonal antibody specifically detects TFPI2 in IHC. It exhibits reactivity toward Human.

Quick Overview for TFPI2 antibody (AA 100-235) (ABIN7865306)

Target: TFPI2 (Tissue Factor Pathway Inhibitor 2 (TFPI2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TFPI2 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: TFPI2-13028

Product Details anti-TFPI2 Antibody

Binding Specificity: AA 100-235

Purpose: TFPI2 (Tissue Factor Pathway Inhibitor 2) (Marker of Ovarian Carcinoma) Antibody

Specificity: The extrinsic pathway of blood coagulation is initiated by contact of plasma factor VII with tissue factor, a cellular membrane glycoprotein that normally is segregated from the bloodstream but can be exposed after tissue injury or newly synthesized in endothelial cells or leukocytes after stimulation by endotoxin and cytokines. Inhibition of Factor VIIa tissue factor activity requires a plasma component (tissue factor pathway inhibitor (TFPI), lipoprotein-associated coagulation inhibitor (LACI) or extrinsic pathway inhibitor (EPI)) and factor Xa. TFPI directly inhibits factor Xa, and, in an Xa-dependent fashion, also inhibits the Factor VIIa tissue factor catalytic complex. TFPI is a multivalent, Kunitz-type proteinase inhibitor that circulates in association with plasma lipoproteins VLDL, LDL, and HDL. TFPI-2 (also known as placental protein 5) is a related glycoprotein that was originally isolated from human placenta.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa100-235) of human TFPI2 protein (exact sequence is proprietary)

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for TFPI2

Target: TFPI2 (Tissue Factor Pathway Inhibitor 2 (TFPI2))

Alternative Name: TFPI2

Background:

PP5, REF1, TFPI-2

Human placenta, spleen or prostate.

Molecular Weight: 27-32kDa

Gene ID: 7980, 438231

UniProt: P48307