CD276 antibody (AA 100-300)

Catalog No. ABIN7859000

This Mouse Monoclonal antibody specifically detects CD276 in IHC. It exhibits reactivity toward Human.

Quick Overview for CD276 antibody (AA 100-300) (ABIN7859000)

Target: CD276

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD276 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: B7H3-4348

Product Details anti-CD276 Antibody

Binding Specificity: AA 100-300

Purpose: CD276 / B7-H3 Antibody

Specificity: T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory molecules. One such molecule, B7-H3 (B7-homolog 3, also designated B7RP-2) belongs to the B7 immunoglobulin superfamily. Soluble B7-H3 binds a putative receptor on activated T-cells that is distinct from CD28, CTLA-4, ICOS and PD-1. Widely expressed on nonlymphoid tissues, B7-H3 costimulates proliferation of both CD4+ and CD8+ T cells. The ability of B7-H3 to stimulate Th1 and cytotoxic-T cell responses suggest that it may have antitumor activity. B7-H3 interactions may play a role in regulating cell-mediated immune responses against cancer, implicating B7-H3 as a potential therapeutic tool.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa100-300) of human CD276 protein (exact sequence is proprietary)

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for CD276

Target: CD276

Alternative Name: CD276

Background:

4Ig B7 H3, B7 homolog 3, B7-H3, B7H3, B7RP-2, CD276, CD276 antigen, CD276 Molecule, Costimulatory molecule

hepatocellular carcinoma or lung carcinoma., Human tonsil, Placenta

Molecular Weight: B7-H3 isoforms: 57/34/53/57 kDa, glycosylated B7-H3: 90-110 kDa

Gene ID: 80381, 77873

UniProt: Q5ZPR3

Pathways: Cancer Immune Checkpoints