Luteinizing Hormone antibody (AA 100-300)

Catalog No. ABIN7859022

The Mouse Monoclonal anti-Luteinizing Hormone antibody is suitable to detect Luteinizing Hormone in samples from Human. It has been validated for IHC.

Quick Overview for Luteinizing Hormone antibody (AA 100-300) (ABIN7859022)

Target: Luteinizing Hormone (LH)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Luteinizing Hormone antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: LHCGR-7398

Product Details anti-Luteinizing Hormone Antibody

Binding Specificity: AA 100-300

Purpose: Luteinizing Hormone / Choriogonadotropin Receptor (LHCGR) Antibody

Specificity: Recognizes a protein of 78-85 kDa, which is identified as Luteinizing hormone / choriogonadotropin receptor. Luteinizing hormone plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Choriogonadotropin production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone / choriogonadotropin receptor (LHCGR) as a seven transmembrane, G protein-coupled receptor glycoprotein. LHCGR influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of LHCGR on breast carcinoma correlates in part to the degree of tumor differentiation. LHCGR -positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 100-300) of human LHCGR protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for Luteinizing Hormone

Target: Luteinizing Hormone (LH)

Alternative Name: Luteinizing Hormone

Target Type: Hormone

Background:

Gonadotropin receptor, GTHR-II, HHG, LCGR, LGR2, LH-R, LH/CG-R, LH/CGR, LHCGR, LHR, LHRHR, LSH-R, Luteinizing hormone receptor, Luteinizing hormone/choriogonadotropin receptor, Lutropin choriogonadotropic receptor, Lutropin-choriogonadotropic hormone receptor, ULG5

HepG2 or Jurkat cells. Human ovarian carcinoma.

Molecular Weight: 78-85kDa

Gene ID: 3973, 468490